Ovine pulmonary adenocarcinoma opa, caused by jaagsiekte sheep retrovirus. Transcriptional response of ovine lung to infection with jaagsiekte. Morbidity and mortality ovine pulmonary adenocarcinoma is rare in sheep less than 7. Ovine pulmonary adenocarcinoma results from infection by jaagsiekte sheep retrovirus jsrv, a member of the genus betaretrovirus in the retroviridae. Eradication programs have been based on extensive slaughtering, because no. Ovine pulmonary adenocarcinoma opa is an infectious lung cancer of sheep. The virus infects and transforms type ii alveolar epithelial cells and clara cells. Ovine respiratory syncytial virus definition of ovine. Ovine pulmonary adenocarcinoma in slaughtered sheep. November farm newsletter diagnosis of ovine pulmonary. Jaagsiekte sheep retrovirus jsrv is a unique oncogenic virus with distinctive biological properties. Technical note tn684 september 2017 elec ovine pulmonary. Tumours are generally uncommon in domestic livestock, but small ruminants are unusual because two neoplastic diseases ovine pulmonary adenocarcinoma opa and enzootic nasal adenocarcinoma of sheep and goats can affect many animals in countries and flocks where they are endemic.
Veterinary investigation reports for submissions in the 5 years 20122016 show that in north. Morbidity and mortality ovine pulmonary adenocarcinoma is rare in sheep less than 79 months of age. Opa is caused by an oncogenic betaretrovirus, jaagsiekte sheep retrovirus jsrv. Without preventative vaccines and serological diagnostic tools for assay of opa, identification of jsrv based on reverse transcription polymerase chain reaction rtpcr is very important for prevention and control. Diagnosis and prevalence of ovine pulmonary adenocarcinoma in.
A novel lentivirus was isolated from south african sheep with experimentally transmitted lung adenocarcinoma. The major core protein p27 of the putative opc virus crossreacts with antibodies to p27. Opa is believed to be the most important disease that can. Ovine pulmonary adenocarcinoma opa is a contagious, viral, neoplastic disease of the lungs of sheep and more rarely of goats. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Pulmonary adenomatosis, ovine is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Ovine pulmonary adenocarcinoma opa is a contagious lung cancer of sheep previously known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma.
The virus replicates predominantly in the tumor cells, is released into the airways, and is found in respiratory secretions. Oct 23, 20 ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by jaagsiekte sheep retrovirus jsrv. Characteristics of a novel lentivirus derived from south. First confirmation by pcr of jaagsiekte sheep retrovirus in. Opa jaagsiekte moredun group moredun research institute. Ovine pulmonary adenocarcinoma opa is a contagious tumour of the lungs of sheep. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte is an infectious and fatal lung disease of sheep.
Substitution of the primary antibody by tris buffer at ph 7. The legacy of this great resource continues as the merck veterinary manual in the us and canada and the msd manual outside of north america. Ovine pulmonary adenocarcinoma merck veterinary manual. Diagnosis and phylogenetic analysis of ovine pulmonary. The virus works by causing a proliferation of the alveolar lining cells in the lungs, causing mass amounts of fluid to be produced. Opa is generally considered a chronic wasting disease with progressive respiratory distress leading to emaciation, but it may be that early lung lesions predispose to secondary bacterial pneumonia causing. It is generally found in young adult sheep, and is characterised by tumour cell growth in the lungs, with metastasis to the regional lymph nodes. Jaagsiekte sheep retrovirus is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Clinical, gross pathology, histopathology and electron microscopy of the ovine pulmonary adenocarcinoma opa, jaagsiekte either natural or experimentally induced in sheep, goat and moufflon are described. Maedivisna mv and ovine pulmonary adenocarcinoma opa are chronic diseases of retroviral aetiology that affect adult sheep and have been reported in many sheeprearing countries worldwide. Jaagsiekte sheep retrovirus jsrv and enzootic nasal tumour virus.
Diagnosis of ovine pulmonary adenocarcinoma daisy rankin ovine pulmonary adenocarcinoma opa is a contagious lung tumour caused by the jaagsiekte sheep retrovirus jsr. Ovine pulmonary adenocarcinoma opa is a contagious lung tumour of sheep resulting from infection with a betaretrovirus called jaagsiekte sheep retrovirus jsrv. Ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by jaagsiekte sheep retrovirus jsrv. Data analysis was performed using the software tool rest 72, which. Opa is common in sheep, and it is most commonly observed in china. Telomerase activation in a model of lung adenocarcinoma. Lung adenocarcinoma originates from retrovirus infection of. First confirmation by pcr of jaagsiekte sheep retrovirus in ireland. Ovine pulmonary adenocarcinoma opa is a naturally occurring lung cancer of sheep caused by retrovirus infection and has several features in common with adenocarcinoma of humans, including a.
The disease is also commonly known as jaagsiekte, ovine pulmonary carcinoma, or sheep pulmonary adenomatosis. Ovine pulmonary adenocarcinoma opa is a retrovirusinduced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. Enzootic nasal adenocarcinoma ena is a contagious neoplasm of the secretory epithelial cells of the nasal mucosa of sheep and goats. Lung tumor development and spontaneous regression in lambs. Ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by. Development of superficial lung lesions monitored on farm. Jaagsiekte, ovine pulmonary carcinoma, ovine pulmonary adenomatosis, sheep pulmonary adenomatosis ovine pulmonary adenocarcinoma is a contagious viral disease of sheep that results in pulmonary neoplasia in some animals. It has never been cultured from infected animals, which must be identified with viral nucleic acids or antigens. These diseases can be transmitted experimentally, but do not seem to affect cattle or other animals. It is associated with the betaretrovirus, enzootic nasal tumor virus entv, but a causative relationship has yet to be demonstrated. Adenoassociated virus vector mediated expression of an oncogenic. High infection rates and disease prevalence can develop during initial infection of flocks, leading to onfarm economic losses and animal welfare issues in sheep with advanced disease.
Opa is believed to be the most important disease that. Transmission of jsrv occurs predominantly through the aerosol route by inhalation of. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte, is a. Pulmonary adenomatosis, ovine pulmonary adenomatosis, ovine is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings.
The lungs fail to deflate and are mottled with coalescing to diffuse proliferative areas pale pink with red areas of atelectasis. The study of pulmonary adenomatosis, ovine has been mentioned in research publications which can be found using our bioinformatics tool below. First confirmation by pcr of jaagsiekte sheep retrovirus. Opa is caused by a retrovirus called jaagsiekte sheep retrovirus jsrv. Bronchioloalveolar carcinoma not related to jaagsiekte. Ultrasonographic examination is very useful to differentiate these various types of pneumonias in the live animal. Telomerase activity in opa and the potential involvement of the kinase akt in telomerase activation and regulation of cell proliferation were investigated. Opa is generally considered a chronic wasting disease with progressive respiratory distress leading to emaciation, but it may be that early lung lesions predispose to secondary bacterial pneumonia causing sudden. It has been reported from europe, asia, africa, and south and north america. The clinical signs of opa comprise cachexia, moist respiratory sounds, dyspnoea and coughing that are not specific for opa. The virus causes an infectious, bronchiolaralveolar lung tumour of sheep. Ovine pulmonary adenocarcinoma opa, also known as sheep pulmonary adenomatosis spa, is a naturally occurring and experimentally inducible lung cancer of sheep that shares symptomatic and histopathologic characteristics with human bronchioloalveolar carcinoma bac. Retrovirusinduced ovine pulmonary adenocarcinoma, an.
The disease presents itself with signs of wasting and nasal discharge, progressing to. Proteins overexpressed in ovine pulmonary adenocarcinoma. Ovine pulmonary adenocarcinoma opa is a lung cancer strikingly similar to the pneumonictype mixed invasive adenocarcinoma with a predominant bronchioloalveolar component in humans. Pdf retrovirusassociated neoplasms of the respiratory. Ent is an adenocarcinoma of the secretory epithelial cells of the nasal glands and is associated with two different retroviruses. The tumour cells then produce more of the virus which can infect new areas of the lung or other sheep. Progressive pneumonia in sheep and goats respiratory system.
The virus induces neoplastic transformation of secretory epithelial cells of sheep lung. A very interesting animal model for human lung adenocarcinoma exists. In classical opa, the presence of oedematous fluids and copious mucoid secretions in the airways is a pathogonomic symptom. Pathology of ovine pulmonary adenocarcinoma springerlink. Ovine pulmonary adenocarcinoma opa, caused by jaagsiekte sheep retrovirus jsrv, is characterised by the development of invariably fatal lung tumours primarily in adult sheep. Results also indicate that the virus has a diverse geographical. Diagnosis and control of ovine pulmonary adenocarcinoma. Jsrv has been described in various breeds of sheep, rarely in goats, and does not appear to infect other animals 4, 5.
Additional resources for ovine pulmonary adenocarcinoma. Ovine pulmonary adenocarcinoma opa, also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. Jsrv is also known as the pulmonary adenomatosis virus. This study was aimed to detect ovine pulmonary adenocarcinoma opa in sheep flocks affected with pulmonary disorders at organized farm. Jsrv is the only virus causing a naturally occurring lung cancer ovine pulmonary adenocarcinoma, opa and possessing a major structural protein. Progressive pneumonia in sheep and goats respiratory. Ovine pulmonary adenocarcinoma opa is a naturallyoccurring neoplastic lung disease caused by the jaagsiekte sheep retrovirus jsrv 1518. It is also commonly known as jaagsiekte, ovine pulmonary carcinoma or sheep pulmonary adenomatosis.
It is caused by a virus, known as jaagsiekte sheep retrovirus jsrv, which infects cells in the lung making them form tumours. Ovine pulmonary adenocarcinoma opa is a transmissible lung cancer of sheep caused by jaagsiekte sheep retrovirus jsrv. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte or ovine pulmonary. This is the virus that killed dolly, the famous cloned ewe, at 6 years old. Pathology and pathogenesis of ovine pulmonary adenocarcinoma. Ovine pulmonary adenocarcinoma is caused by a virus that can be transmitted between sheep in respiratory secretions or milk.
The disease is regarded as a valuable translational preclinical research model for studying human lung cancer, overcoming many of the limitations associated with current murine models. Opa is relatively common in ireland, where it is on the dafm list of notifiable diseases part b, although less common here than in northern ireland or the uk. Interestingly, eradication of ovine pulmonary adenocarcinoma has been. Jsrv is the virus that is the cause of the contagious lung tumors in sheep called ovine pulmonary adenocarcinoma opa. Ovine pulmonary adenocarcinoma opa national advice hub t. In this study, 14dayold lambs were experimentally infected via nebulization with cellfree tumor filtrates derived from. Tissue sections of sheep lung naturally affecetd by ovine pulmonary adenocarcinoma opa and unaffected sheep lung were used as positive and negative controls, respectively. Ovine pulmonary carcinoma opc is a contagious pulmonary neoplasia with a suspected retroviral etiology. The oncogenic exogenous jaagsiekte sheep retrovirus jsrv, responsible for ovine pulmonary adenocarcinoma, has several endogenous counterparts termed enjsrvs. The first aim of this study was to monitor the development of opa with minimally invasive, realtime observations of animals experimentally infected with jsrv as well as ovine lentivirus.
Lung adenocarcinoma originates from retrovirus infection. Ovine pulmonary adenocarcinoma opa is a naturally occurring and experimentally inducible lung cancer of sheep caused by jaagsiekte sheep retrovirus jsrv. Ovine pulmonary adenocarcinoma iowa state university. Retrovirusinduced ovine pulmonary adenocarcinoma, an animal.
Ovine pulmonary adenocarcinoma was eradicated from iceland by slaughtering all sheep in affected areas. These diseases can be transmitted experimentally, but do not seem to affect cattle or other. Ovine pulmonary adenocarcinoma is a transmissible lung cancer of sheep. Nov 07, 2001 ovine pulmonary adenocarcinoma opa is a retrovirusinduced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. Ovine pulmonary adenocarcinoma opa is an infectious lung disease of sheep.
Advances in the study of transmissible respiratory tumours in small. The etiologic agent of opa, jaagsiekte sheep retrovirus jsrv, is unique among retroviruses for having a specific tropism for the differentiated epithelial cells of the lung, and it is. Opa was first described in south africa in the 19th century where it was called jaagsiekte derived from the afrikaans for chasing sickness, because affected sheep have the appearance of having being chased and the. Experimental transmission of enzootic nasal adenocarcinoma. A novel translational ovine pulmonary adenocarcinoma model. The disease has also been called jaagsiekte, after the afrikaans words for chase jaag and sickness siekte, to describe the respiratory distress observed in an animal out of breath from being chased, indicating the breathing difficulty experienced by. Microsatellites in immunerelevant regions and their. Pulmonary adenomatosis, ovine harvard catalyst profiles. Ovine pulmonary adenocarcinoma uk lung cancer in sheep caused by a virus jaagsiekte sheep retrovirus, which is always fatal virus is spread between sheep by respiratory routes and also via colostrum and milk tips for control if you dont have it already.
Ovine pulmonary adenocarcinoma opa, also known as ovine pulmonary adenomatosis and jaagsiekte, is a contagious neoplasm affecting the lungs of sheep, which is caused by jaagsiekte sheep retrovirus jsrv. Mv is a slow virus infection of sheep leading to a progressing lymphoproliferative disease that affects multiple organs, but primarily the lungs, where. Ovine pulmonary adenomatosis ovine pulmonary adenocarcinoma, jaagsiekte, opa is a disease caused by jaagsiekte sheep retrovirus jsrv a member of the genus betaretrovirus. Research of pulmonary adenomatosis, ovine has been linked to neoplasms, adenomatosis, pulmonary, malignant neoplasm of lung, adenocarcinoma, lung neoplasms. Differential diagnoses of progressive pneumonia include pulmonary adenocarcinoma, pleural abscesses, and pulmonary caseous lymphadenitis. Ovine pulmonary adenocarcinoma, ultrasound ovine pulmonary adenocarcinoma opa is a contagious, viral, neoplastic disease of the lungs of sheep and more rarely of goats. This disease factsheet on ovine pulmonary adenocarcinoma covers the importance of the disease, aetiology, geographical distribution, species affected, transmission, clinical signs, postmortem lesions, morbidity, mortality, diagnosis, and disease control. Identifying the causative agent for a neoplastic disease and implications for human lung cancer the infectious etiology of chronic diseases your browsing activity is empty. Most natural cases of opa appear in animals 14 years old. An influx of macrophages is the predominant local immune. The disease presents itself with signs of wasting and nasal discharge, progressing to respiratory distress as the tumours take up space in the. Ovine pulmonary carcinoma and enzootic nasal tumor. Embryo transfer may be used to save the genetic potential from valuable flocks that are euthanized. Diagnosis and prevalence of ovine pulmonary adenocarcinoma in lung tissues of naturally infected farm sheep, veterinary world, 94.
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