Formulation and evaluation of gastroretentive floating. Application and advancement of microsphere as controlled. Pdf formulation of floating microspheres of nizatidine. Preparation of floating microspheres of dextromethorphan hbr floating microsphere of dxm hbr was prepared by emulsion solvent evaporation technique. Loading into preformed microspheres has an advantage of removing all impurities from microsphere preparation. Formulation development of floating microspheres of cefditoren. Preparation of omeprazole floating microspheres the floating micro spheres were prepared by solvent evaporation method. Preparation of eudragit e100 microspheres by modified solvent evaporation method vandana singh 1 and amrendra kumar chaudhary2 1translam institute of. Development and evaluation of floating microspheres of verapamil. Floating microspheres were prepared by solvent evaporation method using distilled water as continuous phase. A novel approach for gastro retention article pdf available in world journal of pharmacy and pharmaceutical sciences.
Preparation and in vitro characterization of porous carrierbased. Eudragit s 100, rs 100, rl 100, l 100 and l 100 55 were used to prepare hollow microspheres. The main aim of the present investigation is to formulate omeprazole loaded floating microspheres by solvent evaporation technique. Preparation and in vitro characterization of porous. The objective of present study was to prepare floating microspheres of azithromycin to improve its bioavailability by increasing residence time in the stomach 4. Preparation and evaluation of calcium silicate based. The floating microspheres were taken for micromeritic properties such as bulk density, tapped density, carrs index, hausners ratio, angle of repose. The polymer content was a mixture of eudragit rs 100 hydroxypropylmethylcellulose hpmc k4m. Solvent evaporation method the sodium alginate microspheres were prepared by solvent evaporation. Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of oncedaily formulations. The measured weight was divided by the total amount of drug and polymers which were used for the preparation of the microspheres to obtained percentage yield.
Preparation and characterization of gastroretentive. The prepared microspheres were collected and weighed from different formulations. Weight of floating micr ospheres percentage yield x 100. The recent developments of fdds including approaches to design singleunit and multipleunit floating systems, mechanism of floating microspheres, methods of preparation of hollow microsphere, list of polymers used in hollow microspheres. Preparation of microspheres gated key process parameters that affected the characteristics of plga microspheres, such as their. Preparation of microspheres of losartan potassium using natural polymers method used. Formulation and invitro evaluation of mucoadhesive. During the preparation of microspheres or after the formation of microspheres by incubating. Development and evaluation of hollow microspheres of. Mehta abstract consisting of i calcium silicate cs as porous carrier. Floating microspheres 100 mg were orally administered in suspension form to the animals in group i and nonfloating microspheres were administered to group ii, followed by a sufficient.
Hollow microsphere promises to be a potential approach for gastric retention. The present study involves preparation and evaluation of floating microspheres of verapamil hydrochloride for improving the drug bioavailability by prolongation. Loading into preformed microspheres has an advantage of removing all impurities from microsphere preparation before the drug is incorporated. These are gastro retentive drug delivery dosage systems grdds based on noneffervescent approach. Preparation and evaluation of floating microspheres of. The drug to polymer ratio was used to prepare the different formulation. This organic phase was added slowly to 100 ml of 1. Preparation of microsphere floating microsphere containing metformin hydrochloride was prepared using emulsion solvent diffusion technique19. General method for preparation of floating microspheres floating microspheres containing ofloxacin hydrochloride were prepared by an emulsification solvent evaporation technique soppimath et al.
Preparation of floating microspheres floating microspheres were prepared by ionotropic gelation method. Improved bioavailability through floating microspheres of lovastatin. The accumulation of the carrier at the target site allow them to deliver the drug locally. Floating microspheres 100 mg were orally administered in suspension form to the animals in group i and nonfloating microspheres were administered to group ii, followed by a sufficient volume of drinking water. Optimization of methods for the preparation of famotidine. Surface morphology of floating microspheres by scanning electron microscopy drug entrapment efficiency was found to be optimum 61. Research paper preparation and characterization of serratiopeptidase containing microspheres j. Preparation of polylactidecoglycolide microspheres and. Both natural and synthetic polymers have been used to prepare floating microspheres. The drug and polymer in different proportions are weighed, the polymer was codissolved into previously cooled mixture of ethanol. The various buoyant preparations include hollow microspheres, granules, powders, tablets, capsules, pills and laminated films.
Application and advancement of microsphere as controlled delivery system. Diagnostic microspheres, used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides. A controlledrelease system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation. Floating drug delivery systems fddss are expected to remain buoyant in a lasting way upon the gastric contents. Formulation, optimization and evaluation of floating microspheres of captopril. Research paper preparation and characterization of. The purpose of this study is to formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method. Formulation, optimization and evaluation of floating. Chitosanbased floating microspheres of trimetazidin. A well designed controlled drug delivery system can. The objectives were preparation of floating microspheres of lovastatin by using pure polymers and blends of polymers, characterization and evaluation of the. Preparation of ritonavir floating microspheres 5 the floating microspheres containing ritonavir were prepared by orifice ionic gelation technique. To this dispersion, desired polymer in different concentrations was mixed in suitable proportion and stirring is continued. Accurately weighed amount of drug was dispersed uniformly in aqueous mucilage of sodium alginate with stirring.
The microspheres were prepared by nonaqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose hpmc k 15 m, ethyl. Accurately weighed drug and polymers in different ratios are dissolved in the solvents like ethanol and dichloromethane 1. Gastroretentive drug delivery system, microspheres, floating microspheres, lansoprazole. Microencapsulation techniques using ethyl acetate as a. A drug excipients compatibility study was performed using ftir. Floating microspheres of cp were prepared by solvent evaporation technique using hydroxypropyl methylcellulose hpmc k4m and ethyl. The objective of the present investigation is to formulate multiparticulate gastroretentive dosage form of nizatidine, a h2receptor antagonist widely prescribed in gastric ulcers, duodenal. Of microspheres theoretical wgt to be preparedloading 100 x actual amt. Accurately weighed amount of drug was dispersed uniformly in aqueous mucilage of. Preparation and evaluation of calcium silicate based floating microspheres of amoxicillin m. The aim of present study involves preparation and characterization of floating microspheres using trimetazidin dihydrochloride as a model drug to increase the residence time in the stomach without contact with the mucosa, floating microspheres. It can be used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides.
The effect of various formulation variables on the size and drug release was investigated. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. The present study deals with an attempt to develop hollow floating microspheres of clarithromycin for gastro retention using eudragit polymers prepared by emulsion solvent diffusion method. Development and characterization of floating microspheres of esomeprazole magnesium trihydrate by solvent evaporation method html full text.
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